Characterization of a Novel Bacterial Secretion System

Grant number: 1027812 | Funding period: 2012 - 2014

Completed

Abstract

In this study we will characterize a novel bacterial secretion system that we have discovered. This system mediates the secretion of proteins from the bacterial cell and their attachment to the cell surface. This system is essential for the virulence of a bacterium associated with severe gum disease. The chacterization of this system may offer opportunities for the development of new treatments to target this disease.

Related publications (2)

Porphyromonas gingivalis Type IX Secretion Substrates Are Cleaved and Modified by a Sortase-Like Mechanism

DG Gorasia, PD Veith, D Chen, CA Seers, HA Mitchell, YY Chen, MD Glew, SG Dashper, EC Reynolds

2015-01-01

The type IX secretion system (T9SS) of Porphyromonas gingivalis secretes proteins possessing a conserved C-terminal domain (CTD) t..

Protein substrates of a novel secretion system are numerous in the Bacteroidetes phylum and have in common a cleavable C-terminal secretion signal, extensive post-translational modification, and cell-surface attachment

PD Veith, NA Nor Muhammad, SG Dashper, VA Likić, DG Gorasia, D Chen, SJ Byrne, DV Catmull, EC Reynolds

2013-10-04

The secretion of certain proteins in Porphyromonas gingivalis is dependent on a C-terminal domain (CTD). After secretion, the CTD ..

University of Melbourne Researchers

Eric Reynolds

Paul Veith

Stuart Dashper